There are several reasons why cannabis edibles might not work for some people. Here are some potential factors:

1. Metabolism and Digestive System

• Liver Enzymes: The enzyme CYP2C9 in the liver metabolizes THC into 11-hydroxy-THC, which is more potent and crosses the blood-brain barrier more effectively. Variations in this enzyme’s activity can affect how strongly you feel the effects. If your liver metabolizes THC slowly or not effectively, the psychoactive effects might be reduced.
• Digestive System: Edibles need to be broken down and absorbed through the digestive system. Issues like poor digestion or gastrointestinal conditions can affect absorption.

2. First-Pass Metabolism

When THC is ingested, it undergoes first-pass metabolism in the liver, which can significantly reduce the amount of THC that enters the bloodstream. This can vary widely among individuals, leading to differing experiences with edibles.

3. Dosage

• Low Dosage: The dosage in edibles might be too low for your tolerance level. If you have a high tolerance to THC, you might need a higher dose to feel the effects.
• Inconsistent Dosing: Homemade or poorly manufactured edibles can have inconsistent THC distribution, leading to unpredictable effects.

4. Individual Differences

• Tolerance: Regular cannabis users often develop a tolerance, meaning they need higher doses to achieve the desired effects. If you consume cannabis frequently, your tolerance might be higher than average.
• Genetic Factors: Genetic differences can influence how your body processes THC. Some people naturally metabolize THC faster or slower due to their genetic makeup.

5. Consumption Method

• Empty vs. Full Stomach: Edibles consumed on an empty stomach might be absorbed more quickly than those consumed after a large meal.
• Type of Edible: Different types of edibles (e.g., gummies, chocolates, baked goods) might have different absorption rates. The presence of fats in the edible can enhance THC absorption since THC is fat-soluble.

6. Psychological Factors

• Expectations and Mindset: Your mental state and expectations can influence how you perceive the effects of THC. If you’re anxious or skeptical, you might be less likely to feel the effects.

Tips to Improve Edible Effectiveness

1. Increase Dosage Gradually: Start with a low dose and increase gradually to find the right amount for you. Be cautious to avoid overconsumption.
2. Consume with Fats: Eat edibles with a meal containing fats to enhance absorption.
3. Choose Quality Products: Ensure you’re using edibles from reputable sources with consistent dosing.
4. Check for Drug Interactions: Some medications can interfere with THC metabolism. Consult a healthcare professional if you’re taking other medications.

If you’ve tried these suggestions and still don’t feel the effects, it might be helpful to consult with a healthcare professional or a cannabis specialist to explore your individual situation further.